| 세션명 | 의료용 고분자 부문위원회 (I) |
|---|---|
| 발표장 | 제2회장 |
| 논문코드 | 1L2-7 |
| 발표일 | 2021-10-21 |
| 발표시간 | 16:50-17:15 |
| 논문제목 | Therapeutic Evaluation of A Mannose Receptor Targetable Nanodrug in Atherogenic Foam cells and Atherosclerosis Animal Models |
| 발표자 | 박경순 |
| 발표자 소속 | 중앙대학교 |
| 저자 | 박경순† |
| 소속 | 중앙대학교 |
| 논문초록 | Macrophage-derived foam cells paly critical roles in the development of atherosclerosis. Thus, they are considered as important target biomarkers for atherosclerosis therapy. Our group has developed a macrophage mannose receptor (MMR)-targeted nanodrug loaded with lobeglitazone (MMR-Lobe). The MMR-Lobe had a high binding affinity to foam cells, and it could efficiently promote cholesterol efflux via LXRα, ABCA1, and ABCG1 pathways, and inhibit pro-inflammatory mediators. Using optical diffraction tomography, we identified lipid droplets in foam cells and quantitatively evaluated the therapeutic effects of MMR-Lobe. Also, long-term delivery of MMR-Lobe markedly reduced both plaque burden and inflammation in atherogenic mice without undesirable systemic effects. Furthermore, short-term treatment of MMR-Lobe showed a robust acute anti-inflammatory effect on inflamed plaque in coronary-sized arteries and shifted the plaque composition to a stable phenotype. |
THE POLYMER SOCIETY OF KOREA